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This is a translation of the table of contents. One article is translated and freely available.

SPOT ON
Profiteering with orphan drugs … 450-fold price increase within seven years

NEW ON THE MARKET
Baricitinib (OLUMIANT) and tofacitinib (XELJANZ) against rheumatoid arthritis

THERAPY FROM A CRITICAL VIEWPOINT
CANVAS trial with canagliflozin (INVOCANA) – second endpoint trial with an SGLT-2 inhibitor
Bioresorbable coronary stents: disappointing results

a-t READERS QUESTIONS AND COMMENTS
Glatiramer acetate generic CLIFT

IN BRIEF
SCORE 2 trial: bevacizumab (AVASTIN) versus aflibercept (EYLEA) in retinal vein occlusion
No benefit of high dose baclofen (LIORESAL, generics) in alcohol-dependent patients
Azithromycin gel against borreliosis?

CURRENT ADR NETWORK REPORT
Genital mycosis with empagliflozin (JARDIANCE)

SIDE EFFECTS
Fatal liver failure with daclizumab (ZINBRYTA)  free article 
Cardiovascular side effects with brimonidine (MIRVASO)

e a-t ON THE INTERNET
Osteonecrosis of the external auditory canal with denosumab (PROLIA, XGEVA)
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