Acute neurological symptoms with pregabalin (LYRICA): After a single dose of 150 mg of the anticonvulsant pregabalin (LYRICA; cf. a-t 2004; 35: 104, 113) for the symptomatic treatment of postherpetic neuralgia, a 60-years old woman had to be admitted to hospital because of acute symptoms such as blurred speech, gait and stationary ataxia, generalised myoclonus, focal dystonia of the hand and agitation. The complaints resolved fully within a day of stopping pregabalin (NETZWERK report No. 13.468). As isolated symptoms, the described motor abnormalities are known with most antiepileptics and can be explained, for example, as functional disturbance of the cerebellum and basal ganglia, (BATTINO, D. et al.: in: DUKES, M. N. G. [ed.]: "Meyler's Side Effects of Drugs", 14th edition, Elsevier, Amsterdam 2000, page 188). In clinical studies with pregabalin before licencing, 5% of the patients suffered from ataxia (EMEA: European evaluation report LYRICA, July 2004). The incidence of myoclonus, which can originate at any level of the motor system, is probably underestimated with the new agent (HUPPERTZ, H.-J. et al.: Epilepsia 2001; 42: 790-2). Drug-induced dystonias occur most often after taking neuroleptics, more rarely with anticonvulsants. They usually occur shortly after the first ingestion or when the dose is increased, can be treated with anticholinergics such as biperiden (AKINETON etc.) and usually resolve without sequelae. They are often experienced as threatening and frightening by those affected (VAN HARTEN, P.N. et al.: BMJ 1999; 319: 623-6). The complex neurological findings that occurred in this patient have to our knowledge not so far been described with pregabalin.