Early benefit assessment: is the Pharmaceutical Market Restructuring Act in Germany (AMNOG) a break on innovation?

Thrombin inhibitor dabigatran (PRADAXA) for nonvalvular atrial fibrillation

Protease inhibitor boceprevir (VICTRELIS) for chronic hepatitis C

Are pre-filled syringes without integrated needle protection obsolete?

Liver damage with analgesic flupirtine (KATADOLON, generics)

E.g. clozapine (LEPONEX, generics): bedwetting with atypical antipsychotics in adults

QT interval prolongation with SSRI citalopram (CIPRAMIL, generics)